Depression is one of the most e, various approaches have been used in treating these disorders; however, scommon psycholo-gical disorders and of the most common causes of suicides. Other disorders with high comorbidity with depression are some of anxiety disorders. To datome researchers suggested that the use of cognitive behavioral therapy in combination with spiritual-religious techniques is much effective in treating anxiety disorders. The purpose of this study was to case-study and research the effectiveness of religion based cognitive behavioral therapy with focus on positive thinking and forgiveness techniques on the diagnosed depression and anxiety signs. One of the clients is a 46 year woman who through clinical interview and MMPI and SCL-90 tests has been diagnosed with depression and anxiety signs. Then, eight therapy sessions based on Khodaayaarifard and Aabedini’s (2015) intervention package were implemented. Results from the comparison of pre-test and post-test figures suggest that the religion based cognitive-behavioral therapy with focus on positive thinking and forgiveness techniques affects depression and anxiety signs. We could conclude that religion based cognitive-behavioral therapy with focus on positive thinking and forgiveness techniques, as a counseling-mixed, consistent with Iran’s culturalreligion context method, is significantly effective in elevating anxiety and depression signs, so far that counselors and psychotherapists can use it in treating clients with religious background